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COL1A2 is a Novel Biomarker to Improve Clinical Prediction in Human Gastric Cancer: Integrating Bioinformatics and Meta-Analysis
Li Rong 1 - Personal Name
Wei Huang 2 - Personal Name
Xiangbo Chi 1 - Personal Name
Pan Zhao 1 - Personal Name
Fengfeng Liu 1 - Personal Name
Gastric cancer is the third most common cause
of cancer-related death in worldwide. It is crucial to tar-
get the key genes controlling pathogenesis in the early
stage of gastric cancer. This study describes an integrated
bioinformatics to identify molecular biomarkers for gas-
tric cancer in patients’ cancer tissues. We reports differ-
ently expression genes in large gastric cancer cohorts
from Gene Expression Ominus (GEO). Our findings re-
vealed that 433 genes were significantly different
expressed in human gastric cancer. Differently expression
gene profile in gastric cancer was further validated by
bioinformatic analyses, co-expression network construc-
tion. Based on the co-expression network and top-ranked
genes, we identified collagen type I alpha 2 (COL1A2)
which encodes the pro-alpha2 chain of type I collagen
whose triple helix comprises two alpha1 chains and one
alpha2 chain, was the key gene in a 37-gene network
that modulates cell motility by interacting with the cyto-
skeleton. Furthermore, the prognostic role of COL1A2
was determined by use of immunohistochemistry on hu-
man gastric cancer tissue. COL1A2 was highly expressed
in human gastric cancer as compared with normal gastric
tissues. Statistical analysis showed COL1A2 expression
level was significantly associated with histological type
of cancer-related death in worldwide. It is crucial to tar-
get the key genes controlling pathogenesis in the early
stage of gastric cancer. This study describes an integrated
bioinformatics to identify molecular biomarkers for gas-
tric cancer in patients’ cancer tissues. We reports differ-
ently expression genes in large gastric cancer cohorts
from Gene Expression Ominus (GEO). Our findings re-
vealed that 433 genes were significantly different
expressed in human gastric cancer. Differently expression
gene profile in gastric cancer was further validated by
bioinformatic analyses, co-expression network construc-
tion. Based on the co-expression network and top-ranked
genes, we identified collagen type I alpha 2 (COL1A2)
which encodes the pro-alpha2 chain of type I collagen
whose triple helix comprises two alpha1 chains and one
alpha2 chain, was the key gene in a 37-gene network
that modulates cell motility by interacting with the cyto-
skeleton. Furthermore, the prognostic role of COL1A2
was determined by use of immunohistochemistry on hu-
man gastric cancer tissue. COL1A2 was highly expressed
in human gastric cancer as compared with normal gastric
tissues. Statistical analysis showed COL1A2 expression
level was significantly associated with histological type
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