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X inactivation in a mammal species with three sex chromosomes
VEYRUNES1 Frederic - Personal Name
PEREZ1 Julie - Personal Name
X inactivation is a fundamental mechanism in eutherian mammals to restore a balance of X-linked gene products between XYmales and XXfemales. However, it has never beenextensively studied ina eutherian species witha sex determination system thatdeviates from the ubiquitous XX/XY. In this study, we explore the X inactivation process in the African pygmy mouseMusminutoides, that harbours a polygenic sex determination with three sex chromosomes: Y, X, and a feminizing mutant X, namedX*; females can thus be XX, XX*, or X*Y, and all males are XY. Using immunofluorescence, we investigated histone modi-fication patterns between the two X chromosome types. We found that the X and X* chromosomes are randomly inactivated inXX* females, while no histone modifications were detected in X*Y females. Furthermore, inM. minutoides, X and X*chromosomes are fused todifferent autosomes, and we were able to show that the X inactivation never spreads into the autosomal segments. Evaluation of X inactivation by immunofluorescence is an excellent quantitative procedure, but it is only applicable when there is a structural difference between the two chromosomes that allows them to be distinguished
Availability
| EB00000003241K | Available |
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Content Type
E-Jurnal
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Subject(s)
Histone modification
X inactivation
African pygmy mouse
Mus minutoides
Polygenic sex determination
Sex-autosome translocation
Specific Detail Info
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Statement of Responsibility
Frederic Veyrunes1, Julie Perez1
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